Treatment of staphylococcal infections with cyclic lipopeptides

Treatment of Generalized Staphylococcal Infections.

[Oxazolidinones, glycopeptides and cyclic lipopeptides].

A review of the chemical structure, pharmacokinetics, spectrum of activity, clinical use, and adverse effects of oxazolidinones (linezolid), glycopeptides, and cyclic lipopeptides (daptomycin) is presented. Oxazolidinones inhibit protein synthesis, and glycopeptides and cyclic lipopeptides act against the bacterial cell wall. The antibacterial spectrum of these agents covers gram-positive patho...

Staphylococcal infections.

977 T HE STAPHYLOCOCCUS problem has been placed high on the agenda of the Public Health Service for this year. Last year it was Asian flu vaccine. The year before it was poliomyelitis vaccine. This year it is the problem of hospital-acquired staphylococens infection. It is pleasing to me to see the position pediatricians have taken as one of the first national organizations to realize the impor...

[Staphylococcal infections].

All the forms of staphylococcal infections require cooperation among microbiologists, immunologists and clinicians. In case of any acute staphylococcus process, the curative tactics is based on an effective chemotherapy sometimes completed by a radical surgical intervention. In case of chronic forms, however, the antibiotics therapy is considered to be problematic. It is the specific immunother...

Staphylococcal Infections

Epidemiology and Transmission 487 Staphylococcus aureus 487 Coagulase-Negative Staphylococci 488 Microbiology 489 Staphylococcus aureus 489 Coagulase-Negative Staphylococci 490 Pathogenesis of Disease 490 Virulence Factors of Staphylococcus aureus 490 Epithelial Attachment and Invasion 490 Innate Immune Resistance 491 Secreted Toxins 492 Quorum Sensing and Regulation of Virulence Factor Express...